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Yes. Several vitamins have some sort of side effect when taken in megadose quantities. Vitamin A most readily comes to mind. Remember that there's usually a very large range between the recommended daily allowance of a vitamin and it's upper limit (the point at which toxicity would become an issue). You'd need to consume at least several hundred percent (sometimes several thousand percent) of the RDA of a vitamin for a period before toxicity would become a problem. Don't fret if you happen to have a Centrum multi-vitamin and a few servings of Total throughout the day. On the otherhand, don't go about popping vitamins like candy and be aware of toxicity levels if you are taking supplements. Good resource on vitamin toxicity levels.

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Q: Are vitamins toxic if you take to much off them?
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